RAF Typhoon FGR4s have operated alongside French aircraft in a coordinated attack against an hidden munitions depot in Syrian territory used by the IS group, according to the UK's MoD.
The site, located using surveillance, was thought to be storing arms and explosives, the release indicated, and was located in mountainous terrain just north of the historic site of Palmyra in Syria's central region.
"The RAF jets employed Paveway IV guided bombs to hit a several entry passages providing entry to the facility... preliminary assessments are that the strike was effective," the MoD said.
There was no indication of any civilian impact in the attack late on Saturday and all the aircraft made a safe return, the MoD added.
The Typhoon fighters were supported by a Voyager tanker plane.
IS - also known as the so-called Islamic State - enforced militant control over parts of both Syria and Iraq until 2019.
"This operation shows British leadership, and resolve to operate in unison with allied nations, to stamp out any re-emergence of IS and their harmful and extremist ideologies in the area," the British Defence Secretary the Defence Secretary remarked.
UK warplanes have performed overwatch operations over Syria to "prevent any efforts to regroup" of Islamic State subsequent to its routing at the Baghuz confrontation in 2019, the authorities noted.
"I extend gratitude to every member of our armed forces involved in this operation for their professionalism and their bravery," Healey commented. "They were among a great many British troops deployed over the festive period. This operation, to take out militants who pose a risk to our security, highlights how British military are prepared to act, throughout the year, protecting the UK domestically and influential overseas."
In December, the US military carried out what it described as a "large-scale strike" against IS targets in the country, following an assault claimed the lives of two American soldiers and a civilian linguist in Palmyra.
The U.N. reports IS still has between 5,000 and 7,000 fighters in both countries.
